Boca Raton, FL, November 13-15
Regulatory guidance for clinical trials targeting cognition in schizophrenia highlights the importance of functional capacity and recommends inclusion of a meaningful functional measure as a co-primary endpoint. We developed the Virtual Reality Functional Capacity Assessment Tool (VRFCAT) as a reliable assessment of functional capacity for use in such trials. Using a realistic virtual reality environment, the VRFCAT assesses the ability to complete activities associated with a shopping trip. The present study assessed the validity, sensitivity, and reliability of the VRFCAT. VRFCAT performance was compared to performance on the UCSD Performance-based Skills Assessment (UPSA-2-VIM), and the relationship between the VRFCAT and cognitive performance on the MATRICS Consensus Cognitive Battery (MCCB) was assessed.