CLINICAL TRIALS ON ALZHEIMER’S DISEASE (CTAD)
BARCELONA, SPAIN, NOVEMBER 5-7, 2015
Clinical trials devote considerable effort and resources to rater training and quality assurance of ADAS-Cog endpoints. To examine the efficacy of these efforts in improving ADASCog reliability, we evaluated the impact of central data review on ADAS-Cog test-retest reliability. Results indicate that central data review improved ADAS-Cog ICCs and substantially reduced the rate of missing data.