Cognitive impairments affect the majority of patients with schizophrenia and these impairments predict poor long term psychosocial outcomes.  Treatment studies aimed at cognitive impairment in patients with schizophrenia not only require demonstration of improvements on cognitive tests, but also evidence that any cognitive changes lead to clinically meaningful improvements.

Ruse SA, Davis VG, Atkins AS, Krishnan RR, Fox KH, Harvey PD, Keefe, RSE. Development of virtual reality assessment of everyday living skills.  Journal of Visualized Experiments, 2014; 86: 1-8.  (PMCID: PMC4174921).