A computerized, self-administered test of verbal episodic memory in elderly patients with mild cognitive impairment and healthy participants: A randomized, crossover, validation study
Randall L. Morrison, Huiling Pei, Gerald Novak, Daniel I. Kaufer, Kathleen A. Welsh-Bohmer, Stephen Ruhmel, Vaibhav A. Narayan
Introduction: Performance of “Revere”, a novel iPad-administered word-list recall (WLR) test, in quantifying deficits in verbal episodic memory, was evaluated versus examiner-administered Rey Auditory Verbal Learning Test (RAVLT) in patients with mild cognitive impairment and cognitively normal participants.
Methods: Elderly patients with clinically diagnosed mild cognitive impairment (Montreal Cognitive Assessment score 24–27) and cognitively normal (Montreal Cognitive Assessment score >28) were administered RAVLT or Revere in a randomized crossover design.
Results: A total of 153/161 participants (Revere/RAVLT n= 75; RAVLT/Revere n = 78) were randomized; 148 (97%) completed study; 121 patients (mean [standard deviation] age: 70.4 [7.84] years) were included for analysis. Word-list recall scores (8 trials) were comparable between Revere and RAVLT (Pearson’s correlation coefficients: 0.12–0.70; least square mean difference [RevereRAVLT]: -0.84 [90% CI, 21.15; 20.54]). Model factor estimates indicated trial (P ,<.001), period (P ,< .001) and evaluation sequence (P= .038) as significant factors. Learning over trials index and
serial position effects were comparable.
Discussion: Participants’ verbal recall performance on Revere and RAVLT were equivalent. 2018 Janssen Research & Development. Published by Elsevier Inc. on behalf of the Alzheimer’s
Association. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Keywords: Alzheimer’s disease; Episodic memory; Mild cognitive impairment; Computerized assessment; Validity study
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